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filingDate 1998-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2000-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AR-012878-A1
titleOfInvention A COMPOUND DERIVED FROM 5'-DEOXICITIDINE, ITS USE, A PROCESS TO MANUFACTURE IT, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND IT, AND A KIT THAT INCLUDES SUCH COMPOSITION.
abstract Compounds derived from 5'-deoxycytidine represented by the general formula I, in which R1 is a hydrogen atom or a group easily hydrolyzable under physiological conditions; R2 is a hydrogen atom or a -CO-OR4 group, where R4 is a linear or branched, saturated or unsaturated hydrocarbon group consisting of one to fifteen carbon atoms, or a group of formula - (CH2) nY (where Y is cyclohexyl or phenyl; n is an integer from 0 to 4); R3 is a hydrogen, bromine, iodine or cyano atom, a C1-4 alkyl group, (which may be substituted by halogen atom (s)), a vinyl oethynyl group (which may be substituted by halogen atom (s) , C1-4alkyl, cycloalkyl, aralkyl, or an aromatic ring that may have one or more heteroatom (s)), or an aralkyl group that may be substituted, for use in medical therapy, especially antitumor therapy. A process for manufacturing them, pharmaceutical compositions comprising them, kits comprising such compositions, and the use of the compounds for the manufacture of a medicament for the treatment of tumors.
priorityDate 1997-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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