http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-012712-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4180fc57a693864e2ce2dbfd64a9278 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate | 1998-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-012712-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF 6-0-MONOSTERS OF [1S- (1 ALPHA, 6 BETA, 7 ALPHA, 8 BETA, 8 ALPHA BETA)] - OCTAHIDRO-1, 6, 7, 8-INDOLIZINATETROL |
| abstract | A procedure for the preparation of a compound of formula (I) where R is C1-10 alkyl, phenyl, or substituted phenyl, consisting of treating a compound of formula (II) with bis (tributyltin) oxide in an organic solvent selected from the group consisting of O-xylene, m-xylene, p-xylene and mixed xelenes and then treat the reaction mixture with a compound of formula (III) where X is halogen and R is defined as above. A procedure for obtaining and purification of the compound of formula (IV): where R is C1-10 alkyl, phenyl or substituted phenyl and Yes an acid selected from the group consisting of hydrogen bromide, hydrogen chloride, sulfuric acids, phosphoric acid, nitric acid, formic acid, acetic acid, propionic acid, succinic acid, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, ascordibo acid, alpha-ketoglutaric acid, glutamic acid, aspartic acid, malei acid co, hydroxymaleic acid, pyruvic acid, phenylacetic acid, benzoic acid, p-aminobenzoic acid, anthranilic acid, p-hydroxybenzoic acid, salicylic acid, hydroxyethanesulfonic acid, ethylene sulfonic acid, toluenesulfonic acid, naphthalenesulfonic acid, naphthalenesulfonic acid, Compounds (I) and (IV) are useful in the treatment of various retroviral infections, diabetes and in the inhibition of tumor metastasis. |
| priorityDate | 1997-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.