http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-012634-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_313a5f9e3decaee61deaaaa1c737390c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-91215 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-95 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
| filingDate | 1998-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-012634-A1 |
| titleOfInvention | QUINAZOLINE BASED COMPOUND, FAMACEUTICAL COMPOSITION THAT UNDERSTANDS IT, METHOD TO SYNTHESIZE IT, ITS USE, METHODS OF MODULATION OF THE DESERINE / TREONIN PROTEIN-KINASE FUNCTION AND IN VITRO METHOD TO IDENTIFY COMPOUNDS THAT MODULATE |
| abstract | A quinazoline-based compound having a structure shown in formula I, II, or III, where: (i) Z is oxygen, NX1, or sulfur, den X is selected from the group consisting of hydrogen, saturated or unsaturated alkyl, and 5- or 6-membered heteroaryl or aryl ring groups; (ii) n is 0, 1,2, 3 or 4; (iii) A1, A2, A3, A4, A5, and A6 are independently selected from the group consisting of carbon, nitrogen, oxygen, and sulfur; (iv) R1 and R2 are independently selected from the group consisting of: (a) hydrogen; (b) saturated or unsaturated alkyl; (c) NX2X3, where X2 and X3 are independently selected from the group consisting of hydrogen and saturated or unsaturated alkyl; and (d) halogen or trihalomethyl; (e) heteroaryl or aryl ring five to six members; (v) R3, R4, R5, R6, R7, R8, R9 and R10 are independently selected from the group consisting of: (a) hydrogen, with the proviso that at least one of R3, R4, R5, R6, R7, R8, R9 and R10 is a group other than hydrogen if R2 is -NH2; (b) saturated or unsaturated alkyl, where said R8 is not methyl when R2 is -NH2 and when n = 1; (c) NX2X3 where X2 and X3 are independently selected from the group consisting of hydrogen, alkyl saturated or unsaturated, and 5- or six-membered heteroaryl or aryl rings; (d) halogen or trihalomethyl, where said R8 is not chlorine or fluorine when R2 is -NH2 and when n = 1; (e) a ketone of the formula -CO-X4, where X4 is selected from the group consisting of hydrogen, alkyl, and six-membered heteroaryl or aryl groups; (f) a carboxylic acid of formula - (X5) n-COOH or ester of formula - (X6) n-COO-S7, where X5, X6; and X7 and are independently selected from the group consisting of 5- or 6-membered alkyl and heteroaryl or aryl groups and where n is 0 or 1; (g) an alcohol of formula (X8) n -OH or a group |
| priorityDate | 1997-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.