http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-012631-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8be6a6c990669567cc455d32b00535e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0202 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-087 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 |
| filingDate | 1998-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-012631-A1 |
| titleOfInvention | SERINE PROTEASE INHIBITORS |
| abstract | A compound of the formula (I) R1SO2-B-X-Z-C (O) -Y where R! is R2OOC- (CHR2) m -o R2NH-CO- (CHR2) m or is selected from (1-12C) alkyl, (2-12C) alkenyl, said groups may be optionally substituted by (3-12C) cycloalkyl, alkoxy ( 1-6C), OH, COOR2, CF3 or halogen, and between aryl (6-14), aralkyl (7-15C) and aralkenyl (8-16), the aryl groups of which can optionally be substituted by alkyl ( 1-6C), cycloalkyl (3-8C), alkoxy (1-6C), OH, COOH, CF3 or halogen; m is 1, 2 or 3; each R2 group is independently H, (1-12C) alkyl, (3-8C) cycloalkyl, (6-14C) aryl or (7-15C) alkyl, the aryl groups of which may be substituted by (1-6C) alkyl , aklkoxy (1-6C) or halogen; B is a bond, an amino acid deformula -NH-CH [(CH2) 9C (O) OH] -C (O) - or an ester derivative thereof where p is 1, 2 or 3, Gly, D-1-Piq , D-3-Piq, D-1-Tiq, D-3-Piq, D-3-Tiq, D-3-Tiq, D-Atc, Aico an L- or D-amino acid with a hydrophobic, basic side chain or neutral; X is an amino acid with a hydrogoba, glutamine, serine, threonine, cyclic amino acid side chain optionally containing an additional heteroatom selected from N, O, or S and optionally substituted by (1-6C) alkyl, benzyloxy, or oxo, or X is acidic 2-amino-isobutyric, -NR2-CH2-C (O) - or the fragment of formula O where n is 2, 3 or 4, W is CXH or N and R3 is H, phenyl or (1-6C) alkyl; said groups may be optionally substituted by hydroxy, (1-6C) alkoxy, COOH, COO (1-6C) alkyl, CONH2 or halogen; Z is lysine or 4-aminocyclohesylglycine; Y is -NH- (1-6C) alkylene-C6H5, the phenyl group of which may be substituted by (1-6C) alkyl, (1-6C) alkoxy or halogen, oY is -OR4 or -NR5R6, where R4 is H, (2-6C) alkyl or benzyl, and R5 and R6 are independently H, optionally substituted (1-6C) alkoxy or (1-6C) alkyl |
| priorityDate | 1997-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.