http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-012489-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d608dce60e3ea87ec7fb0b40f1cb31a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-30 |
| filingDate | 1998-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-012489-A1 |
| titleOfInvention | CORTICOTROPIN RELEASE FACTOR THIOPHENOPYRIDINE ANTAGONISTS. PROCEDURE FOR ITS PREPARATION, THE USE OF THE SAME IN THE PREPARATION OF A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM, PROCEDURE FOR THE PREPARATION OF SUCH COMPOSITION, AN INTERMEDIATE COMPOUND AND |
| abstract | Thiophenopyridines corticotropin releasing factor antagonists of formula (I), including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, where X is S or SO2; R1 is C1-6 alkyl, NR5 R6, OR6, or SR6; R2 is C1-6alkyl, C1-6alkyloxy or C1-6alkylthio; R3 is Ar1 or Het1; R4 is hydrogen, or C1-6 alkyl; R5 is hydrogen, C1-8 alkyl, mono- or di (C3-6 cycloalkyl) methyl, C3-6 cycloalkyl, C3-6 alkenyl, hydroxyC1-6alkyl, C1-6alkylcarbonyloxyC1-6alkyl or C1-6alkyloxy alkyl C1-6; R6 is C1-8 alkyl, mono- or di (C3-6 cycloalkyl) methyl, Ar2CH2, C1-6 alkyloxy C1-6 alkyl, hydroxyalkyl C1-6, thienylmethyl, furanylmethyl, C 1-6 alkylthio, C 1-6 alkyl mono or di (C 1-6 alkyl) amino C 1-6 alkyl, di (C 1-6 alkyl) amino, C 1-6 alkylcarbonyl C 1-6 alkyl; or R5 and R6 taken together with the nitrogen atom to which they are attached can form a pyrrolidinyl, piperidinyl, homopiperidinyl, or morpholinyl group, optionally substituted with C1-6alkyl or C1-6alkyloxyC1-6alkyl; and Ar1 is phenyl; phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, C1-6alkyl, trifluoromethyl, hydroxy, cyano, C1-6alkyloxy, benzyloxy, C1-6alkylthio, nitro, amino and mono- or di - (C1-6 alkyl) amino; Ar2 is phenyl, phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, di (C1-6alkyl) aminoC1-6alkyl, trifluoromethyl; and Het1 is pyridinyl, pyridinyl substituted with 1, 2 or 3 substituents each independently selected from halo, C1-6alkyl, trifluoromethyl, hydroxy i, cyano, C1-6alkyloxy, benzyloxy, C1-6alkylthio, nitro amino and mono- or di- (C1-6 alkyl) amino; Y |
| priorityDate | 1997-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.