http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-012488-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8fa73639d3e2c89ec8e445daf969b7ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-42 |
| filingDate | 1998-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-012488-A1 |
| titleOfInvention | A COMPOUND DERIVED FROM QUINO- AND QUINAZOLINS ANTAGONISTS OF THE CORTICOTROPIN RELEASING FACTOR, A PROCEDURE FOR THEIR PREPARATION, A COMPOSITION THAT INCLUDES THEM, A PROCEDURE FOR THE PREPARATION OF SUCH COMPOSITION, INTERMEDIARIES AND THE USE OF SUCH COMPOUNDS. |
| abstract | It refers to the quino- and quinazoline-derived compounds of formula (I), including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, where X is N or CH; R1 is C1-6 alkyl, NR6R7, OR6, SR7; in the case where X is N, R2 represents hydrogen, C1-6 alkyl, C1-6 alkyloxy or C1-6 alkylthio; in the case where X is CH, R2 represents C1-6 alkyl, C1-6 alkyloxy or C1-6 alkylthio; R3 is Ar1o Het1; R4 and R5 are each independently selected from hydrogen, halo, C1-6 alkyl, C1-6 alkyloxy, trifluoromethyl, cyano, nitro, amino, and mono- or di (C1-6 alkyl) amino, R6 is hydrogen, C1- alkyl 8, mono- or di (C3-6 cycloalkyl) methyl, cycloalkyl or C3-6, alkenyl C3-6, hydroxyC1-6alkyl, C1-6alkylcarbonyloxy, C1-6alkyl or C1-6alkyloxyC1-6alkyl; R7 is C1-8alkyl, mono- or di- (C3-6cycloalkyl) methyl, Ar2CH2, C1-6alkyloxyC1-6alkyl, hydroxyalkylC1-6, thienylmethyl, furani-methyl, C1-6alkylthio, C1-6alkyl, mono- or di- (C1-6alkyl) amino C1-6alkyl; or R6 and R7 taken together with the nitrogen atoms to which they are attached can form a pyrrolidinyl, piperidinyl, homopiperidinyl or omorpholinyl group, optionally substituted with C1-6 alkyl or C1-6 alkyloxy C1-6 alkyl; and Ar1 and Ar2 are each optionally substituted phenyl; and optionally substituted Hetl is pyridinyl; that it has CRF receptor antagonist properties; Pharmaceutical compositions containing such compounds as active ingredients, methods of treating disorders related to CRF hypersecretion such as depression, anxiety, abuse of addictive substances, by administering an effective amount of a compound of formula (I). |
| priorityDate | 1997-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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