| abstract |
When chloromethyl 17alpha-ethoxycarbonyloxy-11Beta-hydroxyandrosta-1,4-dien-3-one-17Beta-carboxylate, hereinafter more batchprednol etabonate, a substance that has excellent anti-inflammatory and antiallergic activity, it is used as a low local application drug In the form of a aqueous suspension, its particles tend to agglomerate and precipitate. Long-term stabilization of the suspension has been achieved through the formulation of loteprednol etabonate with a mixture of microcrystalline cellulose-carmellose sodium. On the other hand, the resulting suspension has a greatly improved intranasal retention and does not cause skin or mucosal irritation. |