| abstract |
A naphthalene derivative of formula (I), wherein: A is a bond -CH2-, -CH (OH) -, -C = NOR4-, -C (O) -, -NR5-, -O- or - S (O) n-, where n is an integer from 0 to 2, R4 is hydrogen or alkyl and R5 is hydrogen, alkyl or acyl; Z is a group represented by formula (B), (C), (D), or (E), where n1 is 0 to 3; X is O or S; R1 is hydrogen, alkyl, alkenyl, alkynyl, halogenalkyl, cycloalkyl, cycloalkylalkyl, alkoxy, alkenyloxy, cycloalkyloxy, or halogenalkyloxy, acyl, alkyloxy, cycloalkyloxy, cycloalkyloxy, cycloalkyloxy, cycloalkyloxy, cycloalkyloxy, cycloalkyloxy, C = BOR4, -C = NR9R10, -CO-NR9R10, -OCONR9R10 or -OSO2R11; R2 is hydrogen, alkyl, alkoxy, halogen, nitro, or -NR9R10; and R3 is -SO2R12 or -SO2R13R14 where: R12 is alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or alkoxycarbonylalkyl; R13 is hydrogen, alkyl or acyl; and R14 is hydrogen, alkyl or, haloalkyl, cycloalkyl, cycloalkylalkyl, alkenyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, aralkyl, heteroaralkyl, heterocycle, heterocycloalkyl, acyl, hydroxyl, or alkoxy; or R13 and R1 4 together with the nitrogen atom to which they are attached form a heterocycloamino group; and its pharmaceutically acceptable salts, prodrugs, individual isomers, and mixtures of isomers; its use, pharmaceutical composition that includes it and a procedure for its preparation. The derivative is an inhibitor of prostaglandin G / H synthase and is useful as a therapeutically active substance especially in inflammatory diseases and autoimmune diseases. |