| abstract |
CNS-derived sulfonamide derivatives and a sulfonamide compound of formula (I) or a salt thereof, comprising: P is phenyl, naphthyl, a bicyclic heterocyclic ring, or is a 5- to 7-membered heterocyclic ring, each containing one of 1 to 4 heteroatoms selected from oxygen, nitrogen or sulfur; A is a single bond, a C1-6 alkylene group or a C1-6 alkenylene group; R1 is halogen, C1-6 alkyl optionally substituted with one or more halogen atoms, C3-6 cycloalkyl, CO-C1-6 alkyl, C1-6 alkoxy, OCF3, hydroxy, hydroxy-C1-6 alkyl, hydroxy-C1- alkoxy 6, C1-6 alkoxy-C1-6 alkoxy, acyl, nitro, amino, alkylamino or dialkylamino, cyano or R1 is phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5- to 7-membered heterocyclic ring, each containing from 1 to 4 heteroatoms selected from oxygen, nitrogen, or sulfur; n is 0, 1, 2, 3, 4, 5, or 6; R2 is hydrogen, C1-6 alkyl or aryl-C1-6 alkyl; R3 is a group R5 or together with R5 forms a group (CH2) 2O or (CH2) 3O or R3 is linked to R2 to form a group (CH2) 2 or (CH2) 3; R4 is -X (CH2) p-R6, where X is a single bond, CH2, or NH or N-C1-6alkyl and p is 0 to 6 and R6 is a 5- to 7-membered, optionally substituted, heterocyclic ring which it contains 1 to 3 heteroatoms selected from nitrogen, sulfur or oxygen, or R6 is NR7R8, where R7 and R8 are independently hydrogen, C1-6 alkyl or aryl-C1-6 alkyl; and R5 is hydrogen, halogen, C 1-6 alkyl, C 3-6 cycloalkyl, CO-C 1-6 alkyl, C 1-6 alkoxy, hydroxy, hydroxy-C 1-6 alkyl, hydroxy-C 1-6 alkoxy, C 1-6 alkoxy-alkoxy C1-6, acyl, nitro, trifluoromethyl, cyano or aryl, procedures for pharmaceutical preparation and composition. |