| abstract |
Compounds of formula (I) where G is as described in the specification; or the stereoisomers, pharmaceutically acceptable salts, and hydrates thereof. The compounds are Apo B / MTP inhibitors and are useful in the treatment of various disorders and conditions such as atherosclerosis, pancreatitis, obesity, hypercholesterolemia, hypertriglyceridemia, hyperlipidemia, and diabetes. The compounds of this invention are also useful in conjunction with other pharmaceutical agents including cholesterol biosynthesis inhibitors, and cholesterol absorption inhibitors, especially HMG-CoA reductase inhibitors and HMG-CoA synthase inhibitors; HMG-CoA reductase expression inhibitors, CETP inhibitors; bile acid complexing agents; fibrates, cholesterol absorption inhibitors; ACAT inhibitors, squalene synthase inhibitors, ion exchange resins, antioxidants, and niacin. It is also directed to intermediates and useful procedures in the preparation of compounds of formula (I). |