| abstract |
A compound having a structure according to formula (I), wherein: R1 is H; R2 is hydrogen, alkyl or acyl; Ar is COR3 or SO2R4; and R3 is alkoxy, aryloxy, heteroaryloxy, alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamin or, dialkylamino, arylamino and alkylarylamino; R4 is alkyl, heteroalkyl, aryl, or heteroaryl, substituted or unsubstituted; X is O, S, SO, SO2, or NR5, where R5 is independently chosen from hydrogen, alkyl, heteroalkyl, heteroaryl, aryl, SO2R6, COR7, CSR8, PO (R9), or may optionally form a ring with Y or W ; and R6 is alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, diarylamino and alkylarylamino; R7 is hydrogen, alkoxy, ar yloxy, heteroaryloxy, alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, diarylamino and alkylarylamino; R8 is alkyl, aryl, heteroaryl, heteroalkyl, amino, alkylamino, dialkylamino, arylamino, diarylamino and alkylarylamino; R9 is alkyl, aryl, heteroaryl, heteroalkyl; W is hydrogen or one or more lower alkyl groups, or a heterocycle, or is an alkylene, arylene, or heteroarylene bridge between two adjacent or non-adjacent carbons (thus forming a fused ring); Y is independently one or more of hydrogen, hydroxyl, SR10, SOR4, SO2R4, alkoxy, amino, where the amino group is of the formula NR11, R12, where R11 and R12 are independently chosen from hydrogen, alkyl, heteroalkyl , heteroaryl, aryl, SO2R6, COR7, CSR8, PO (R9) 2; and R10 is hydrogen, alkyl, aryl, heteroaryl; Z is non-existent, a group of spiral form or an oxo group substituted on the erocyclic het ring; n is 1-4; where said structure also includes an optical isomer, diasteromer or |