http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-009300-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_880cc8535f892eca8121f608c316808c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 1997-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-009300-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF CARBAMATE DERIVATIVES OF PHYSOSTIGMINE FROM ESERETOLS AND PROCEDURE FOR OBTAINING AN INTERMEDIARY SUCH PROCEDURE |
| abstract | The product that is prepared has the formula (I) where R is alkyl; R1 is hydrogen, alkyl, cycloalkyl, cycloalkyl alkyl, bicycloalkyl, aryl or arylalkyl; R2 is alkyl, cycloalkyl, cycloalkyl alkyl, bicycloalkyl, aryl, or arylalkyl; or R1 and R2, taken together with the nitrogen atom to which they are attached, form a group of formula (Ia) where Y is hydrogen or alkyl and Z is hydrogen, alkyl, halogen, alkoxy, halogen or trifluoromethyl, and month 0, 1 , or 2, or a pharmaceutically acceptable salt thereof. The procedure consists of (a) contacting a compound of formula (II) as defined herein with reinforced hydrogen bromide to obtain a compound of formula (III) as defined herein; Contacting the reaction mixture containing a compound of formula (III) with: (1) an isocyanate of formula R1NCO or (2) a compound of formula (IV) as defined to obtain a compound of formula (V) as defined herein and contacting the reaction mixture containing the compound of formula (V) with an amine of formula R1R2NH here in the presence of a carboxylic acid of formula R5COOH and forming and isolating the product of formula (I). The preparation of the intermediary (III) is also described. |
| priorityDate | 1996-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 16.