http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-008756-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba045776bcd32d32e3100da8dfce4e28 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-14 |
| filingDate | 1997-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-008756-A1 |
| titleOfInvention | ENZYMATIC PROCESS FOR THE STEREOSELECTIVE PREPARATION OF THERAPEUTIC AMIDES |
| abstract | A method of preparing an optically active compound of formula I where E is selected from nitrogen and CZ, where C is a ring carbon and Z is a substituent as defined below, where: when E is CZ, X and Z are selected of the group consisting of: (A) X is ArY where Y is a bond group selected from carbonyl, sulfinyl and sulfonyl and Ar is selected from the group consisting of phenyl substituted with 0-2 substituents selected from halo, hydroxy, C1-C4 cyano alkyl, and C1-C4 alkoxy; six-membered heteroaryl rings containing 1-2 nitrogen atoms as the sole heteroatoms, five-membered heteroaryl rings containing 1-2 heteroatoms selected from nitrogen, oxygen, and sulfur; and Z is selected from hydrogen, cyano, halo, hydroxy, C1-C4 alkyl and C1-C4 alkoxy; and (B) X is cyano and Z is selected from the group consisting of phenylthio, phenylsulfinyl, and phenylsulfonyl whose phenyl rings are substituted with 0-2 substituents selected from halo, hydroxy, cyano, nitro, C1-C4 alkyl, and C1-C4 alkoxy, and when E is nitrogen, X is independently selected from any of the aforementioned values of X (A); and * is an optically active chiral center, comprising the step of treating a racemic compound of formula II where X and E are as defined above and R1 is alkyl optionally substituted by one or more substituents independently selected from hydroxy, halogen, C1-C4 alkoxy, cyano, C1-C4 alkylamino and C1-C4 with a hydrolase enzyme. The invention also provides useful chiral intermediates to prepare the compound of formula I and enzymatic processes to prepare said chiral intermediates. |
| priorityDate | 1996-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.