abstract |
They are derivatives of alpha-hydroxycarboxylic acids of formula (I) where R is a group of formula -CO-R1, in which R1 has the following meanings: a) hydrogen, b) a succinylimidoxy group; c) a 5-member heteroaromatic group linked by a nitrogen atom, such as pyrrolyl, pyrazolyl, imidazolyl or triazolyl, optionally substituted by one or two halogen atoms or one or two alkyl groups with 1 to 4 carbon atoms or one or two groups alkoxy of 1 to 4 carbon atoms; d) a group of formula (II) in which k is 0, 1 and 2 and p is 1,2,3 and 4, and R9 is C1-C4-alkyl, C3-C7-cycloalkyl, C3-C6-alkenyl, C3-C6 alkynyl or phenyl optionally substituted, with at least one of the following radicals: halogen, nitro, cyano, C1-C4-alkyl, C1-C4 haloalkyl, hydroxy C1-C4-alkoxy, C1-C4 -alkylthio, mercapto , amino, C1-C4-alkyl, C1-C4 dialkylamino; e) R1 can also be an OR10 radical, R10 representing any of the following: hydrogen, the cation of an alkali metal such as lithium, sodium, potassium, or the cation of an alkaline earth metal such as calcium, magnesium or barium as well as an alkyl ammonium ion or physiologically tolerable ammonia; C3-C8cycloalkylC1 -C8-alkyl, CH2-phenyl, which may be substituted by one or more of the following radicals: halogen, nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, hydroxy, C1-C4-alkoxy , C1-C4-alkoxy, mercapto, C1-C4-alkylthio amino, C1-C4 alkylamino, C1-C4-dialkylamino; a C3-C6-alkenyl group or a C3-C6-alkynyl group, these groups for their part being able to carry from one to five halogen atoms; R10 can also be a phenyl radical, which can carry from one to five halogen atoms and / or from one to three of the following radicals: nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, hydroxy, C1-C4 -alkoxy, |