| abstract |
It refers to phenyl amino substituted tricyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, where n is 0 to 2; R1 is hydrogen or alkyl; R2 is halo, hydroxy, amino, alkoxy, or alkyl; R3 is azido or an ethynyl; R4 is hydrogen, alkyl, alkoxy or -S (O) x alkyl, X being = a 2; and Z form a five to eight membered fused aryl or heteroaryl ring. The compounds of formula (I) are useful in the treatment of hyperproliferative disorders, such as cancer. It also relates to pharmaceutical compositions containing the compounds of formula (I). |