| abstract |
Describes a process for the preparation of compounds derived from 2,5- [diamino] -4-hydroxy azahexane of formula (I), where R1 is hydrogen or a suitable amino-protecting group; R2 is unsubstituted or substituted alkyl; R3 is hydrogen, aryl, heterocyclyl, unsubstituted or substituted alkyl, unsubstituted or substituted ocycloalkyl; R4 independently of R1, is hydrogen or a suitable amino-protecting group and m is a number from 1 to 7; and where other suitable protective groups for functional groups may be present, the compounds of which are antivirally active or can be used as starting substances for pharmaceutically active compounds, especially antivirals. The precursor is an oxo compound, which in turn is prepared by hydrogenation with a suitable compound hydride or with hydrogen in the presence of a suitable catalyst and acyl migration from a hydrazone which in turn is preferably prepared from a nitrilovia compound. imino by means of hydrogenation and reaction with a hydrazine derivative which is prepared from an aldehyde by reaction with a reactive derivative of a carboxylic acid in the presence of a cyanide salt, the intermediate compounds required for this; and the processes for preparing said intermediates. |