| abstract |
A compound of formula (I), in which R1 and R2, which may be the same or different and are H, C1-6 alkyl, C3-7 cycloalkyl or aryl; R3 and R4, which may be the same or different and are H, halogen, C1-6alkyl; substituted oaryl; R5 is H or C1-C6 alkyl or; n is an integer 0, 1, or 2; and m is an integer 1, 2, 3, or 4; the dotted line indicates the presence or absence of an additional link; and the pharmaceutically acceptable solvates thereof, pharmaceutical formulations comprising the compounds of formula (1), methods for preparing the compounds and formulations. The compounds and formulations are used to treat conditions resulting from abnormal system performance to melatonin. |