| abstract |
Compounds of the general formula (I) wherein R1-R4 signify hydrogen, halogen, lower alkyl, lower alkoxy, aryl, benzyloxy, lower alkoxy, lower alkyl-sulfanyl, lower alkyl-sulfanyl-lower alkyl, or R1 and R 2 together signify the group -O- (CH2) 2- or - (CH2) 2-O and R5 signifies hydrogen or hydroxyl, as well as their pharmaceutically acceptable salts, in the control or prevention of diseases or disorders of the central nervous system, such as migraine, schizophrenia , anxiety states, sleep disorders, anorexia, Alzheimer's disease, addictions (alcohol, nicotine, benzodiazepine, cocaine etc), as well as disorders resulting from injuries to the head, brain or spinal column, bone marrow and respectively, for the elaboration of the corresponding medicines. |