| abstract |
It refers to a macrolide which has: i) positions 2 to 6 inclusive, of the macrocyclic ring that are provided by a piperidazinylcarboxylic acid residue; and / or ii) positions 7 to 9 inclusive, of the macrocyclic ring that are provided by an aromatic alpha-amino acid residue; and / or iii) positions 10 to 12 inclusive, of the macrocyclic ring that are provided by an aliphatic alpha-amino acid residue In addition, it refers to the use of said macrolide for the preparation of a drug for use as an immunosuppressant, to the use of said macrolide as a reagent in a displacement immunoassay for a cyclosporin or other compounds. than unencyclophilin, to a process to produce said macrolide, to a biologically pure isolate of the Streptomyces sp A92-308110 (DSM 9954) strain or a mutant, recombinant or modified form thereof, which is capable of producing dichomacrolide, and to a pharmaceutical composition that It comprises said macrolide in association with a pharmaceutically acceptable diluent or carrier. |