http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-005473-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2984 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-544 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-645 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 1997-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-005473-A1 |
| titleOfInvention | LIPID AND PEPTIDE CONJUGATES BASIC MEMBRANE DISTURBERS, PEPTIDE, COMPOSITION UNDERSTANDING THEM AND USE OF CONJUGATES AS VECTORS FOR TRANSFECTION |
| abstract | The invention relates to membrane-disrupting basic lipid and peptide conjugates, in particular compounds of the formulas (R-CONH) n-R3 (I) AND (RSS) n-R3 (II) where R is the radical hydrocarbyl of a saturated or unsaturated straight chain or branched chain liftatic catarboxylic acid, or a phospholipid radical with a free valence; R3 is a basic membrane-disrupting peptide with a free valence of one or two carbon atoms, and n is 1 or 2, which can be used as a vector for transfection of a cell with a polynucleotide and another anionic macromolecule; and in compositions that understand them. The invention also relates to the use of the conjugates and optionally an auxiliary lipid and / or a short-chain phospholipid and / or a cationic lipid or other known molecule for transfection, other than a conjugate of this invention, as a vector for the transfection of a cell with a polynucleotide or any other anionic molecule. The Cys-Ile-Gly-Alaa-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro - Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg Peptide -Gln-Gln-NH2 is new and is also part of this invention. |
| priorityDate | 1996-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID456171974 |
Total number of triples: 25.