| abstract |
A dry composition comprising at least one of the active ingredients selected from the group consisting of pharmacologically active proteins and pharmacologically active polypeptides and as a stabilizer, at least one of the hydrophobic stabilizers selected from the group consisting of hydrophobic amino acids, hydrophobic dipeptides and hydrophobic tripeptides. , which have a Hydropathy Index of at least 3. Even when the aforementioned composition is left to dry in a highly humid medium, it retains its dry state for a long period, does not liquefy and hardly loses its pharmacological activity. Examples of suitable hydrophobic amino acids include valine, leucine, isoleucine, or the like. Examples of suitable hydrophobic dipeptides include leucyl valine, isoleucyl valine, isoleucyl leucine, phenylalanyl isoleucine, or the like. Examples of suitable hydrophobic detripeptides include isoleucyl-leucyl-valine, eukyl-valyl-phenylalanine isol, isoleucyl-valyl-isoleucine or the like. |