| abstract |
3-substituted oxindole derivatives, useful as potassium channel modulators, characterized by formula (I), wherein: R is hydrogen, hydroxy ofluoro, R1, R2, R3 and R4 are each independently hydrogen, alkyl from 1 to 4 carbon atoms, halogen, trifluoromethyl, phenyl, p-methylphenyl or p-trifluoromethylphenyl, or R1 and R2, R2 and R3, or R3 and R4 are bonded to each other to form a benzofused ring. R5 is hydrogen or alkyl of 1 to 4 carbon atoms and R6 is chlorine or trifluoromethyl, or a non-toxic, pharmaceutically acceptable salt, solvate or hydrate thereof. |