| abstract |
The invention relates to new derivatives of piperidinylmethyloxazolidin -2-one of formula (I), where: R1 and R2 independently represent unsubstituted or once or twice substituted phenyl moieties, whose substituents can be A, OA, aryloxy with 6- 10 carbon atoms, aralkyloxy with 7-11 carbon atoms, -O- (CH2) nO- (bonded to the phenyl ring in directly contiguous positions or meta position or to each other), -O- (CH2) nOH, Hal , CF3, OH, NO2, NH2, NHA, NA2, NHR3, NAR3, SO2NH3, SO2NHA, SO2NA2, SO2NHR3 (except R3 = SO2A), SO2N (R3) 2, (except R3 = SO2A), or R3; R3 represents COH, CO-alkyl with 1-7 carbon atoms in the alkyl, CO-alkyl-aryl with 8-12 carbon atoms, CO-AR with 7-13 carbon atoms, SO2A; A represents an alkyl moiety with 1-6 carbon atoms, n is 1 OR 2; Hal represents F, Cl, Br or I; as well as its physiologically acceptable salts. The invention also refers to the development of these new compounds and their use as pharmacologically active substances. These compounds act on the central nervous system and present sedative, tranquilizing, neuroliptic and / or antidepressant effects, without being able to verify a considerable catalytic effect. |