http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-003970-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc25c555cd0514a354d64df675e0be15 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 1996-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1998-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-003970-A1 |
| titleOfInvention | NEW ANTAGONIST COMPOUNDS FOR ENDOTHELINE RECEPTORS, PROCEDURE FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, AND PROCEDURE FOR PREPARING THESE PHARMACEUTICAL COMPOSITIONS. |
| abstract | The invention relates to new endothelin receptor antagonist compounds of formula (I), in which: -Y-Z- represents -NR7-CO, -NaC (OR7) - or-N = CR8-; R1 represents Ar; R2 represents COOR6, CN, 1H-tetrazol-5-yl or CONHSO2Ar; R3, R4, R5, independently, represent R6, OR6, S (O) mR6, Hal, NO2, NR6R6, NHCOR6, NHSO2R6, OCOR6, COOR6 or CN; R6 and R6 independently represent H, alkyl of 1 to 6 carbon atoms, benzyl or phenyl; R1 represents (CH2) nAr; R represents Ar or OA; Ar is a phenyl unsubstituted or substituted one, two or three times with R9, R10 or R11 or an unsubstituted naphthyl or a group (II) unsubstituted or substituted one or two times in the phenyl with R7 or R10 or a group (III ) unsubstituted or substituted one or two times in the cyclohexadienyl with R4 or R10; R9, R10, R11 independently represent R6, OR6, Hal, CF3, OCF1, OCHF2, OCH2F, NO2, NR6R6, NHCOR6, CN, NHSO2R6, COOR6, COR6, CONHSO2Ar, O (CH2) nR2, O (CH2) nOR6 or S (O) mR6; E represents CH2, S or O; carbonyl or [C (R6R6)] n; Hal represents F, Cl, Br or I; X represents O or S; m is 0, 1 or 2; n is 1 or 2. |
| priorityDate | 1995-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.