| abstract |
Compounds of formula (I) are described, which inhibit the activity of 1 endothelin. The symbols are defined as follows: R1 and R2 are each attached to a carbon ring and are each independently; (a) hydrogen; (b) alkyl or alkoxy; (c) hydroxyl; (d) halo; or (e) amino; R3 and R4 are both directly attached to a carbon ring and are each independently (a) hydrogen; (b) alkyl, alkene, alkyne, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkene, cycloalkenoalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which can be substituted by Z1, Z2 and Z3; (c) halo; (d) hydroxyl; (e) cyano; (f) nitro; (g) -C (O) H or -C (O) R5; (h) -CO2H or -CO2R5; (i) -Z4-NR6R7; (j) -Z4-N (R10) -Z5-NR8R9; Or (k) R3 and R4 together may also be alkylene or alkenylene, either of which may be substituted with Z1, Z2, Z3 completing a saturated, unsaturated 4- to 8-membered aromatic ring, together with the carbon atoms to which they are United; and the remaining symbols are defined in the description. |