| abstract |
A compound of the formula i wherein n,x,y and ar are as defined herein, useful in the treatment of a condition selected from the group consisiting of arthritis, cancer, tissue ulceration, macular degeneration, restenosis, periodontal disease, epidemolysis bullosa, scleritis, and other diseases characterized by matrix metalloproteinase activity, aids, sepsis, septic shock and other diseases involving the production of tnf. In addition, the compounds of the oresent invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (nsaid's)and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-plantinum, etoposide, taxol, taxotere and other alksloids, such as vincristine, in the treatment of cancer. |