| abstract |
This invention relates to adenosine inhibitors and to nucleoside analogs, c-4' modified pyrrolo[2,3-d]pyrimidine and pyrazolo[3,4-d]pyrimidine nucleoside analogs having activity as adnosine kinase inhibitors. The inention raltes to nucleoside analogs of this kind, having zero substitutions ot two substitutions at the c-4' position of the furanose (sugar)moiety. The invention also relates to the preparation and use of these adenosine kinase inhibitors in the treatment of cardiovascular, and cerebrovascular diseases, inflammation and other diseases which can be regulated by increasing the local concentration of adenosine. |