| abstract |
Abstract: This invention relates to compounds of the formula (1), B wherein the dashed lines represent optional double bonds; A is nitrogen or CR ; B is -NR'R2, -CRW-Q-CR'R'X, -NHCRW0, -OCR'R2R10, -SCR]R2R10, -CR2R10NHR1, -CR^OR1, -CR^^SR1 or -COR2; J and K are each independently nitrogen or carbon and both J and K are not nitrogens: D and E are each selected, independently, from nitrogen, CR4, C=O, C=S, sulfur, oxygen, CR4R6 and NR8, G is nitrogen or carbon; and their use for the prevention or inhibition of a disorder that can be treated by antagonizing CRF. |