| abstract |
Oxazolyl derivatives of formula (i)wherein -a1=a2-=a3=a4- represents a bivalent radical having the formula -ch=ch-ch=ch- (a-1), -n=ch-ch=ch- (a-2), -ch=n-ch=ch- (a-3), -ch=ch-n=ch- (a-4), -ch=ch-ch=n- (a-5), -n=ch-n-ch- (a-6)or -ch=n-ch=n (a-7); r represents hydrogen or c1-4alkyl; r1 represents hydrogen, c1-6alkyl or hydroxy-c1-6alkyl; m represents 1 or 2; d represents c1-4 alkanediyl; b represents nr2, ch2, ,o,s,so or so2 wherein r2 is hydrogen or c1-4alkyl; n represents 0,1 or 2; lrepresents hydrogen; c1-12alkyl; c3-6cycloalkyl; c3-6alkenyl optionally substituted with aryl; c1-6alkylcarbonyl; c1-6alkyloxycarbonyl;arylcarbonyl; arylc1-6alkyloxycarbonyl; or a radical of formula -alk-r3 (b-1);-alk-y-r4 (b-2); -alk-z1-c(=x)-z2-r5 (b-3); or -ch2-choh-ch2-o-r6 (b-4), the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof have antiallergic properties. Compositions containing the same and methods of treating warm-blooded animals suffering from allergic diseases. |