| abstract |
This invention provides caspase inhibitors having the formula (I): wherein R1 is CO2;H, CH2CO2H, or esters, amides or isosteres thereof; R2 and R3 are each independently selected from hydrogen or an optionally substituted C1-C6 aliphatic group; and R4 and R5 are each independently selected from hydrogen, an optionally substituted C1-C6 aliphatic group, or R4 and R5 taken together with the ring to which they are attached form an optionally substituted bicyclic ring. The caspase inhibitors arc useful i'or treating a number of diseases such as cancer, acute inflammatory and autoimmune disorders, ischemic diseases and certain neurodegenerative disorders. |