| abstract |
This invention relates to compounds of general formula (i); or pharmaceutically acceptable salt threof, w, t, y, x, q, r1, r2, and r3 are adefined herein. This invention also relates to compounds of formula (i), depicted above, wherein y is -nh-; t is(2s,3s)-2-phenylpiperridin-3-yl where the phenyl group of said (2s, 3s)-2-phenylpiperridine-3-yl may optionally be substituted with fluro; q is oxygen and is double bonded to the carbon atom to which it is attached, x is methoxy or ethoxy, r1 is hydrogen, methyl or halo-c1-c2 alkyl, w is methylene, ethylene or vinylene; r2 and r3 are independently hydrogen or methyl, or one fo r2 or r3 may be hydroxy, when w is ethylene, r2 and r3 are both methyl, when w is methylene, and r2 and r3 are both hydrogen, when vinylene. The invention is further directed to methods of treating vasrious cns and other disorders using said compounds and pharmaceutical compositions. |