http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AP-1393-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9551ab6d2238287ab50227dfc98f8df3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 1999-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_318e7a7fcdb7a3acdad6ec2374e6f222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52215689de950a40c024ae5f784a55e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3db6d0d15089806fab134dcc623841ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_382b90e54b6245b898af8cb84be97535 |
| publicationDate | 2005-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AP-1393-A |
| titleOfInvention | Indolo [2,1-b] quinazole-6, 12-dione antimalarial compounds and methods of treating malaria therewith. |
| abstract | Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo[2,1-b]quinazoline-6,12-dione compounds of Formula (I), wherein A, B, C, D, E, F, G and H are independently selected from carbon and nitrogen, or A and B or C and D can be taken together to be nitrogen or sulfur, with the proviso that not more than three of A, B, C, D, E, F, G and H are other than carbon; wherein R1 through R8 are independently selected from the group consisting of, but not limited to, the halogens (F, Cl, Br, and I), alkyl groups, trifluoromethyl groups, methoxyl groups, the carboxy methyl or carboxy ethyl group (COOCH3 OR COOCH2CH3), nitro, aryl, heteroaryl, cyano, amino, diakylaminoalkyl, 1-(4-alkylpiperazinyl), and the pharmaceutically acceptable salts thereof; and wherein x is independently selected from the group consisting of any atom especially oxygen, or any side chain necessary to make the indolo [2,1-b]quinazoline-6,12-dione compound a "prodrug" as the term is understood by one of the ordinary skill in the art of medicinal chemistry. In other words, a side chain having a structure where a carbon-nitrogen double bond bears substituents that make the prodrug more water soluble and bioavailable. |
| priorityDate | 1998-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 211.