| abstract |
The present invention provides illudin analogs of general formula (i)where r1 is (ch2)n-x-y or h; n is 0 to 4; x is o or s or n or absent; and y is an optionally substituted (c1-c8)alkyl, (c6-c10)aryl, (c6-c10)aryl(c1-c4)alkyl or cyclo(c3-c6)alkyl optionally comprising one or more heteroatoms; a,pmpsaccharide, an amino acid residue, or h when n is 2-4; r2 is absent; or r1 and r2 together comprise a 5-7-membereed cyclic ring; r3 is (c1-c4)alkyl or h; r4 is h, sch2co2(c1-c4)alkyl,o-(c5-c12)aryl or -s-(c5-c12)aryl; r5 is h, oh or absent; r6 is (c1-c4)alkyl or absent r7; is oh or osi((c1c1-c4)alkyl)3; or r6 and r7 together are ethylenedioxy;r8 is optionally substituted (c1-c4)alkyl; and the bonds represented by ---- are individually present or absent. The invention further provides dmmers comprising analogs for formula (i) |