title |
Inhibition of MDR1 in multidrug resistant human A2780/DX3 cells assessed as accumulation of doxorubicin at 5 times compound concentration that giving 5% antiproliferative activity after 4 hrs by cytofluorimetric assay relative to (Z)-8-(4-chlorophenyl)-5-methyl-8-(pent-2-enyl-oxy)-[1,2,4]oxadiazolo[3,4-c][1,4]thiazin-3(8H)-one |