title |
Antagonist activity against human CCR5 assessed as ratio of inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envelop protein after 20 hrs by beta-galactosidase reporter gene assay in presence of 1 mg/ml of alpha-acid-glycoprotein relative to CCR5 inhibition in absence of alpha-acid-glycoprotein |