http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID439157
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Nidoviral uridylate-specific endoribonuclease (NendoU) domain of coronavirus Nonstructural protein 15 (Nsp15), arterivirus Nsp11, torovirus endoribonuclease, and related proteins. Nidovirus endoribonucleases (NendoUs) are uridylate-specific endoribonucleases which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. NendoUs include Nsp15 from coronaviruses and Nsp11 from arteriviruses, both of which may participate in the viral replication process and in the evasion of the host immune system. This family also includes torovirus NendoUs. Except for turkey coronavirus (TCoV) Nsp15, Mn2+ is generally essential for the catalytic activity of coronavirus Nsp15. Mn2+ is dispensable, and to some extent inhibits the activity of arterivirus (Porcine Reproductive and Respiratory Syndrome virus) PRRSV Nsp11. Coronavirus Nsp15 from Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), human Coronavirus 229E (HCoV229E), and murine hepatitis virus (MHV) form a functional hexamer while Porcine DeltaCoronavirus (PDCoV) Nsp15 has been shown to exist as a dimer and monomer in solution. Nsp11 from the arterivirus PRRSV is a dimer. NendoUs are distantly related to Xenopus laevis Mn(2+)-dependent uridylate-specific endoribonuclease (XendoU) which is involved in the processing of intron-encoded box C/D U16 small, nucleolar RNA. |
| title | NendoU_nv |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12839081 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9567092 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16777628 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3295185 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16672750 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7973131 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15850377 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23955981 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21395827 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3451514 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28915138 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17323550 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9854812 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17311085 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5340325 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18717120 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCK9N7C7 |
Total number of triples: 20.