http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID439099
Outgoing Links
Predicate | Object |
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abstract | second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins. SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues. |
title | MBT_SCML2_rpt2 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19625825 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27646541 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26251576 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5342179 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24945702 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4636691 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17465146 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23469222 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33080967 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26958097 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2517121 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25121242 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18584401 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/541240 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACC2VYT_A |
Total number of triples: 18.