http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID439099

Outgoing Links

Predicate Object
abstract second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins. SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
title MBT_SCML2_rpt2
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19625825
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27646541
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26251576
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5342179
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24945702
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4636691
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17465146
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23469222
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33080967
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26958097
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2517121
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25121242
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18584401
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/541240
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACC2VYT_A

Total number of triples: 18.