http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID439020
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Rcat domain found in cullin-9 (CUL-9) and similar proteins. CUL-9, also called UbcH7-associated protein 1 (H7-AP1), p53-associated parkin-like cytoplasmic protein, or PARC, is a cytoplasmic RBR-type E3 ubiquitin-protein ligase that function as a tumor suppressor and promotes p53-dependent apoptosis. It mediates the ubiquitination and degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells. It is also a critical downstream effector of the 3M complex in the maintenance of microtubules and genome integrity. Moreover, CUL-9, together with CUL-7, forms homodimers and heterodimers, as well as some atypical cullin RING ligase complexes, which may exhibit ubiquitin ligase activity. CUL-9 contains a CPH domain (conserved in Cul7, PARC, and HERC2 proteins), a DOC (DOC1/APC10) domain, cullin homology domains linked with E3 ligase function, and a C-terminal RBR domain previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)] domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been changed to RING1-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR domain uses an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase functions to facilitate the ubiquitination reaction. This model corresponds to the Rcat domain of CUL-9 that is essential for RBR E3 ligase activity and adopts the same fold as the BRcat domain. |
| title | Rcat_RBR_CUL9 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10043058 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10043059 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14099019 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5123726 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4476591 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15317652 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1773716 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21398067 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3750565 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17198788 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2986841 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15968881 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2986846 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7812928 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8IWT3 |
Total number of triples: 18.