http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438984
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | PWWP domain found in bromodomain and PHD finger-containing protein 1 (BRPF1). BRPF1, also called peregrin, or protein Br140, is a multi-domain protein that binds histones, mediates monocytic leukemic zinc-finger protein (MOZ)-dependent histone acetylation, and is required for Hox gene expression and segmental identity. It is a close partner of the MOZ histone acetyltransferase (HAT) complex and a novel Trithorax group (TrxG) member with a central role during development. BRPF1 is primarily a nuclear protein that has a broad tissue distribution and is abundant in testes and spermatogonia. It may be involved in chromatin remodeling. It contains a plant homeodomain (PHD) zinc finger followed by a non-canonical extended PHD (ePHD) finger, C2HC5HC2H, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain. The PHD finger binds to methylated lysine 4 of histone H3 (K4H3), the bromodomain interacts with acetylated lysines on N-terminal tails of histones and other proteins, and the PWWP domain shows histone-binding and chromatin association properties. |
| title | PWWP_BRPF1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21427761 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22751816 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32046286 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20550936 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24158505 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17405454 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24184827 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCNP_001003694 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP55201 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACC3MO8_A |
Total number of triples: 13.