http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438951
Outgoing Links
Predicate | Object |
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abstract | F-box domain found in F-box/LRR-repeat protein 10 (FBXL10) and similar proteins. FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10, F-box protein FBL10, JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. |
title | F-box_FBXL10 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32404043 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18013136 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8778113 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/482193 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24993794 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30334338 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3921839 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6013424 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6694189 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29520631 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7430057 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9413513 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29729267 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11395063 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30357187 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1211599 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2709582 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11498496 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6P1G2 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8NHM5 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ640I9 |
Total number of triples: 24.