conserveddomain/PSSMID438835

Predicate	Object
abstract	high mobility group (HMG)-box found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins. KMT2C, also called myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) or homologous to ALR protein, is a histone H3 lysine 4 (H3K4) lysine methyltransferase that functions as a circadian factor contributing to genome-scale circadian transcription. It is a component of a large complex that acts as a coactivator of multiple transcription factors, including the bile acid (BA)-activated nuclear receptor, farnesoid X receptor (FXR), a critical player in BA homeostasis. The MLL3 complex is essential for p53 transactivation of small heterodimer partner (SHP). KMT2C is also a part of activating signal cointegrator-2 (ASC-2)-containing complex (ASCOM) that contains the transcriptional coactivator nuclear receptor coactivator 6 (NCOA6), KMT2C and its paralog MLL4. The ASCOM complex is critical for nuclear receptor (NR) activation of bile acid transporter genes and is down regulated in cholestasis.
title	HMG-box_KMT2C
isDiscussedBy	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24223300 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32766645 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16321086 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13861751 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27490384 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32923228 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6503818
type	http://purl.obolibrary.org/obo/SO_0000417

Predicate	Subject
has component	http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8BRH4 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8NEZ4

Total number of triples: 12.