http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438715
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins. RNF8 is a telomere-associated E3 ubiquitin-protein ligase that plays an important role in DNA double-strand break (DSB) repair via histone ubiquitination. It is localized in the nucleus and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3), but not with other E2s (UbcH5, UbcH7, UbcH10, hCdc34, and hBendless). It recruits UBC13 for lysine 63-based self polyubiquitylation. Its deficiency causes neuronal pathology and cognitive decline, and its loss results in neuron degeneration. RNF8, together with RNF168, catalyzes a series of ubiquitylation events on substrates such as H2A and H2AX, with the H2AK13/15 ubiquitylation being particularly important for recruitment of repair factors p53-binding protein 1 (53BP1) or the RAP80-BRCA1 complex to sites of DSBs. Specially, RNF8 mediates the ubiquitination of gammaH2AX, and recruits 53BP1 and BRCA1 to DNA damage sites which promotes DNA damage response (DDR) and inhibits chromosomal instability. Moreover, RNF8 interacts with retinoid X receptor alpha (RXR alpha) and enhances its transcription-stimulating activity. It also regulates the rate of exit from mitosis and cytokinesis. RNF8 contains an N-terminal FHA domain, which is a small phosphopeptide recognition module. |
| title | FHA_RNF8 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11101534 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2706402 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6836168 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22227921 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30279392 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14781713 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5249654 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28132273 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29527950 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30805455 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10587036 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29527952 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14523240 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3198026 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15452496 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14640190 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26984028 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32952801 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13476942 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20764875 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 28.