http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438601
Outgoing Links
Predicate | Object |
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abstract | Ubiquitin Thioesterase Otubain-2. Otubain-2 is also called ubiquitin thioesterase OTUB2, deubiquitinating enzyme OTUB2, OTU domain-containing ubiquitin aldehyde-binding protein 2, or ubiquitin-specific-processing protease OTUB2. It is a deubiquitylase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that mediates the deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. OTUB2 plays a role in DNA double-strand break (DSB) response (DDR); it enhances RNF8-mediated ubiquitination in an early phase of the DDR and promotes faster DSB repair but suppresses homologous recombination. It also functions as a cancer stemness and metastasis-promoting factor that deubiquitinates and activates the transcriptional regulators YAP/TAZ, which play important roles in development, physiology, and tumorigenesis and are negatively controlled by the Hippo pathway. OTUB2 belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. It is classified as a family C65 cysteine protease by MEROPS. |
title | OTUB2 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28432186 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8869459 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2704944 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16215604 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26275749 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9311649 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15541758 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21364845 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20838153 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30427901 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/255271 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ96DC9 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9CQX0 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCAAH68058 |
Total number of triples: 17.