http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438601

Outgoing Links

Predicate Object
abstract Ubiquitin Thioesterase Otubain-2. Otubain-2 is also called ubiquitin thioesterase OTUB2, deubiquitinating enzyme OTUB2, OTU domain-containing ubiquitin aldehyde-binding protein 2, or ubiquitin-specific-processing protease OTUB2. It is a deubiquitylase (DUB)/ubiquitin thioesterase (EC 3.4.19.12) that mediates the deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. OTUB2 plays a role in DNA double-strand break (DSB) response (DDR); it enhances RNF8-mediated ubiquitination in an early phase of the DDR and promotes faster DSB repair but suppresses homologous recombination. It also functions as a cancer stemness and metastasis-promoting factor that deubiquitinates and activates the transcriptional regulators YAP/TAZ, which play important roles in development, physiology, and tumorigenesis and are negatively controlled by the Hippo pathway. OTUB2 belongs to the OTU family of cysteine proteases that use a conserved cysteine, histidine, and an aspartate, as the catalytic triad. It is classified as a family C65 cysteine protease by MEROPS.
title OTUB2
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28432186
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8869459
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2704944
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16215604
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26275749
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9311649
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15541758
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21364845
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20838153
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30427901
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/255271
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ96DC9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9CQX0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCAAH68058

Total number of triples: 17.