http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438463

Outgoing Links

Predicate Object
abstract RING finger, HC subclass, found in RING finger protein 20 (RNF20). RNF20, also known as BRE1A or BRE1, is an E3 ubiquitin-protein ligase that forms a heterodimeric complex together with BRE1B, also known as RNF40, to facilitate the K120 monoubiquitination of histone H2B (H2Bub1), a DNA damage-induced histone modification that is crucial for recruitment of the chromatin remodeler SNF2h to DNA double-strand break (DSB) damage sites. It regulates the cell cycle and differentiation of neural precursor cells (NPCs), and links histone H2B ubiquitylation with inflammation and inflammation-associated cancer. Moreover, RNF20 promotes the polyubiquitination and proteasome-dependent degradation of transcription factor activator protein 2alpha (AP-2alpha), a negative regulator of adipogenesis by repressing the transcription of CCAAT/enhancer binding protein (C/EBPalpha) gene. Furthermore, RNF20 functions as an additional chromatin regulator that is necessary for mixed-lineage leukemia (MLL)-fusion-mediated leukemogenesis. It also inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. TFIIS is a factor capable of relieving stalled RNA polymerase II. RNF20 contains a C3HC4-type RING-HC finger at its C-terminus.
title RING-HC_RNF20
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26324290
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20174538
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9324014
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1013186
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10009427
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31668583
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26245387
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10069693
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/371373
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28187029
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19559043
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5VTR2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5DTM8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA2VDP1

Total number of triples: 17.