http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438463
Outgoing Links
Predicate | Object |
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abstract | RING finger, HC subclass, found in RING finger protein 20 (RNF20). RNF20, also known as BRE1A or BRE1, is an E3 ubiquitin-protein ligase that forms a heterodimeric complex together with BRE1B, also known as RNF40, to facilitate the K120 monoubiquitination of histone H2B (H2Bub1), a DNA damage-induced histone modification that is crucial for recruitment of the chromatin remodeler SNF2h to DNA double-strand break (DSB) damage sites. It regulates the cell cycle and differentiation of neural precursor cells (NPCs), and links histone H2B ubiquitylation with inflammation and inflammation-associated cancer. Moreover, RNF20 promotes the polyubiquitination and proteasome-dependent degradation of transcription factor activator protein 2alpha (AP-2alpha), a negative regulator of adipogenesis by repressing the transcription of CCAAT/enhancer binding protein (C/EBPalpha) gene. Furthermore, RNF20 functions as an additional chromatin regulator that is necessary for mixed-lineage leukemia (MLL)-fusion-mediated leukemogenesis. It also inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. TFIIS is a factor capable of relieving stalled RNA polymerase II. RNF20 contains a C3HC4-type RING-HC finger at its C-terminus. |
title | RING-HC_RNF20 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26324290 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20174538 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9324014 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1013186 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10009427 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31668583 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26245387 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10069693 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/371373 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28187029 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19559043 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5VTR2 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5DTM8 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA2VDP1 |
Total number of triples: 17.