http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438454

Outgoing Links

Predicate Object
abstract RING finger, H2 subclass, found in RING finger protein 128 (RNF128) and similar proteins. This subfamily includes RING finger proteins RNF128, RNF133, RNF148, and similar proteins, which belong to a larger PA-TM-RING ubiquitin ligase family that has been characterized by containing an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C-terminal C3H2C3-type RING-H2 finger followed by a putative PEST sequence. RNF128, also known as gene related to anergy in lymphocytes protein (GRAIL), is a type 1 transmembrane E3 ubiquitin-protein ligase that is a critical regulator of adaptive immunity and development. It inhibits cytokine gene transcription, is expressed in anergic CD4+ T cells, and has been implicated in primary T cell activation, survival, and differentiation, as well as in T cell anergy and oral tolerance. It induces T cell anergy through the ubiquitination activity of its cytosolic RING finger. It regulates expression of the costimulatory molecule CD40L on CD4 T cells, and ubiquitinates the costimulatory molecule CD40 ligand (CD40L) during the induction of T cell anergy. Moreover, RNF128 interacts with the luminal/extracellular portion of both CD151 and the related tetraspanin CD81 via its PA domain, which promoted ubiquitination of cytosolic lysine residues. It also down-modulates the expression of CD83 (previously described as a cell surface marker for mature dendritic cells) on CD4 T cells. Furthermore, Rho guanine dissociation inhibitor (RhoGDI) has been identified as a potential substrate of RNF128, suggesting a role for Rho effector molecules in T cell anergy. In addition, RNF128 plays a role in environmental stress responses. It promotes environmental salinity tolerance in euryhaline tilapia. RNF133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase that is mainly present in the cytoplasm of elongated spermatids. It may play a role in sperm maturation through an ER-associated degradation (ERAD) pathway. RNF148 is a testis-specific E3 ubiquitin ligase that is abundantly expressed in testes and slightly expressed in pancreas. Its expression is regulated by histone deacetylases.
title RING-H2_RNF128-like
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12658511
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30893092
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2481129
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20131225
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18051603
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5829428
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/256661
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5799782
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24206469
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7217306
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9D304
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8TEB7

Total number of triples: 15.