http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438451
Outgoing Links
Predicate | Object |
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abstract | RING finger, H2 subclass, found in RING finger protein 43 (RNF43) and similar proteins. RNF43 is a transmembrane E3 ubiquitin-protein ligase that plays an important role in frizzled (FZD)-dependent regulation of the Wnt/beta-catenin pathway. It functions as a tumor suppressor that inhibits Wnt/beta-catenin signaling by ubiquitinating FZD receptor and targeting it to the lysosomal pathway for degradation. miR-550a-5p directly targeted the 3'-UTR of gene RNF43 and regulated its expression. Moreover, RNF43 interacts with NEDD-4-like ubiquitin-protein ligase-1 (NEDL1) and regulates p53-mediated transcription. It may also be involved in cell growth control through the interaction with HAP95, a chromatin-associated protein interfacing the nuclear envelope. Mutations of RNF43 have been identified in various tumors, including colorectal cancer (CRC), endometrial cancer, mucinous ovarian tumors, gastric adenocarcinoma, pancreatic ductal adenocarcinoma, liver fluke-associated cholangiocarcinoma, hepatocellular carcinoma, and glioma. RNF43 contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C3H2C3-type RING-H2 finger followed by a long C-terminal region. |
title | RING-H2_RNF43 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22870298 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5766422 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20115168 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13999641 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14749720 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7230255 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2709865 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8059719 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12065382 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31648047 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29618973 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26950116 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20856631 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3022045 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14795334 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26990163 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10682737 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11407903 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3204146 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1798678 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ68DV7 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5NCP0 |
Total number of triples: 25.