http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438451

Outgoing Links

Predicate Object
abstract RING finger, H2 subclass, found in RING finger protein 43 (RNF43) and similar proteins. RNF43 is a transmembrane E3 ubiquitin-protein ligase that plays an important role in frizzled (FZD)-dependent regulation of the Wnt/beta-catenin pathway. It functions as a tumor suppressor that inhibits Wnt/beta-catenin signaling by ubiquitinating FZD receptor and targeting it to the lysosomal pathway for degradation. miR-550a-5p directly targeted the 3'-UTR of gene RNF43 and regulated its expression. Moreover, RNF43 interacts with NEDD-4-like ubiquitin-protein ligase-1 (NEDL1) and regulates p53-mediated transcription. It may also be involved in cell growth control through the interaction with HAP95, a chromatin-associated protein interfacing the nuclear envelope. Mutations of RNF43 have been identified in various tumors, including colorectal cancer (CRC), endometrial cancer, mucinous ovarian tumors, gastric adenocarcinoma, pancreatic ductal adenocarcinoma, liver fluke-associated cholangiocarcinoma, hepatocellular carcinoma, and glioma. RNF43 contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C3H2C3-type RING-H2 finger followed by a long C-terminal region.
title RING-H2_RNF43
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22870298
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5766422
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20115168
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13999641
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14749720
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7230255
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2709865
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8059719
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12065382
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31648047
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29618973
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26950116
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20856631
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3022045
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14795334
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26990163
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10682737
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11407903
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3204146
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1798678
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ68DV7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5NCP0

Total number of triples: 25.