http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438426
Outgoing Links
Predicate | Object |
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abstract | RING finger, HC subclass, found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2). UHRF2, also known as Np95/ICBP90-like RING finger protein (NIRF), Np95-like RING finger protein, nuclear protein 97, nuclear zinc finger protein Np97, RING finger protein 107, or E3 ubiquitin-protein ligase UHRF2, was originally identified as a ubiquitin ligase acting as a small ubiquitin-like modifier (SUMO) E3 ligase that enhances zinc finger protein 131 (ZNF131) SUMOylation, but does not enhance ZNF131 ubiquitination. It also ubiquitinates PCNP, a PEST-containing nuclear protein. Moreover, UHRF2 functions as a nuclear protein involved in cell-cycle regulation and has been implicated in tumorigenesis. It interacts with cyclins, CDKs, p53, pRB, PCNA, HDAC1, DNMTs, G9a, methylated histone H3 lysine 9, and methylated DNA. It interacts with the cyclin E-CDK2 complex, ubiquitinates cyclins D1 and E1, induces G1 arrest, and is involved in the G1/S transition regulation. Furthermore, UHRF2 is a direct transcriptional target of the transcription factor E2F-1 in the induction of apoptosis. It recruits HDAC1 and binds to methyl-CpG. UHRF2 also participates in the maturation of Hepatitis B virus (HBV) through interacting with HBV core protein and promoting its degradation. UHRF2 contains an N-terminal ubiquitin-like domain (UBL), a tandem Tudor domain (TTD), a plant homeodomain (PHD) domain, a SET- and RING-associated (SRA) domain, and a C-terminal C3HC4-type RING-HC finger. |
title | RING-HC_UHRF2 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9325907 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20843424 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12539182 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12596789 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24208951 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8527976 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5895701 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17967936 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28252143 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3140677 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10001963 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9345800 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7TMI3 |
Total number of triples: 16.