http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438373
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins. The cellular inhibitor of apoptosis protein c-IAPs function as ubiquitin E3 ligases that mediate the ubiquitination of substrates involved in apoptosis, nuclear factor-kappaB (NF-kappaB) signaling, and oncogenesis. Unlike other IAPs, such as XIAP, c-IAPs exhibit minimal binding to caspases and may not play an important role in the inhibition of these proteases. c-IAP1, also known as baculoviral IAP repeat-containing protein BIRC2, IAP-2, RING finger protein 48, or TNFR2-TRAF-signaling complex protein 2, is a potent regulator of the tumor necrosis factor (TNF) receptor family and NF-kappaB signaling pathways in the cytoplasm. It can also regulate E2F1 transcription factor-mediated control of cyclin transcription in the nucleus. c-IAP2, also known as BIRC3, IAP-1, apoptosis inhibitor 2 (API2), or IAP homolog C, also influences ubiquitin-dependent pathways that modulate innate immune signalling by activation of NF-kappaB. c-IAPs contain three N-terminal baculoviral IAP repeat (BIR) domains that enable interactions with proteins, a ubiquitin-association (UBA) domain that is responsible for the binding of polyubiquitin (polyUb), a caspase activation and recruitment domain (CARD) that serves as a protein interaction surface, and a C3HC4-type RING-HC finger at the carboxyl terminus that is required for ubiquitin ligase activity. Livin, also known as baculoviral IAP repeat-containing protein 7 (BIRC7), kidney inhibitor of apoptosis protein (KIAP), melanoma inhibitor of apoptosis protein (ML-IAP), or RING finger protein 50, was identified as the melanoma IAP. It plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is regulated by the inhibition of caspase-3, -7, and -9. Its E3 ubiquitin-ligase-like activity promotes degradation of Smac/DIABLO, a critical endogenous regulator of all IAPs. Unlike other family members, mammalian livin contains a single BIR domain and a C3HC4-type RING-HC finger. The UBA domain can be detected in non-mammalian homologs of livin. |
| title | RING-HC_BIRC2_3_7 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10431923 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24211664 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23521985 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25147786 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32259813 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/237368 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10689477 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16303307 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7785632 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6591142 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16561691 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30941395 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26172080 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33440350 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14523293 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16306491 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3706493 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15858022 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23405583 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16310941 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32199154 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15913490 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28703042 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30755642 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4392431 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25147350 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31525624 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3746027 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13122876 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16006004 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8642593 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7936437 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9116442 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31347537 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 48.