http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438129
Outgoing Links
Predicate | Object |
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abstract | RING finger, H2 subclass, found in RING-box protein 2 (RBX2) and similar proteins. RBX2, also known as CKII beta-binding protein 1 (CKBBP1), RING finger protein 7 (RNF7), regulator of cullins 2 (ROC2), or sensitive to apoptosis gene protein (SAG), is an E3 ubiquitin-protein ligase that protects cells from apoptosis, confers radioresistance, and plays an essential and non-redundant role in embryogenesis and vasculogenesis. It promotes ubiquitination and degradation of a number of protein substrates, including c-JUN, DEPTOR, HIF-1alpha, IkappaBalpha, NF1, NOXA, p27, and procaspase-3, thus regulating various signaling pathways and biological processes. RBX2 is necessary for ubiquitin ligation activity of the multimeric cullin (Cul)-RING E3 ligases (CRLs). RBX2-containing CRLs are involved in the NEDD8 pathway and RBX2 specifically regulates NEDD8ylation of Cul5. It can bind and activate the HIV-1 Vif-Cullin5 E3 ligase complex in vitro. It is also a substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. The inactivation of RBX2 E3 ubiquitin ligase activity triggers senescence and inhibits Kras-induced immortalization. Endothelial deletion of RBX2 causes embryonic lethality and blocks tumor angiogenesis, and may have potential use in anti-angiogenesis therapy of human cancers. Moreover, as a component of the Cullin 5-RING E3 ubiquitin ligase (CRL5) complex, RBX2 regulates neuronal migration through different CRL5 adaptors, such as SOCS7. RBX2 also functions as a redox inducible antioxidant protein that scavenges oxygen radicals by forming inter- and intra-molecular disulfide bonds when acting alone. It contains a C-terminal C3H2C3-type RING-H2 finger that is essential for its ligase activity. |
title | RING-H2_RBX2 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1798572 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5951460 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28699618 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28309987 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2930172 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14754793 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20095043 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14757542 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24935225 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10456287 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/896720 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22748271 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21283828 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7826089 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9UBF6 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9WTZ1 |
Total number of triples: 19.