http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID411845
Outgoing Links
Predicate | Object |
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abstract | fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins. Vigilin, also called high density lipoprotein-binding protein, or HDL-binding protein, is a ubiquitous and highly conserved RNA-binding protein that shuttles between nucleus and cytoplasm presumably in contact with RNA molecules. It may be involved in chromosome partitioning at mitosis, facilitating translation and tRNA transport, and control of mRNA metabolism, including estrogen-mediated stabilization of vitellogenin mRNA. Vigilin is up-regulated by cholesterol loading of cells and functions to protect cells from over-accumulation of cholesterol. It may play a role in cell sterol metabolism. Disruption of human vigilin impairs chromosome condensation and segregation. Vigilin has a unique structure of 14-15 consecutively arranged, but non-identical K-homology (KH) domains which apparently mediate RNA-protein binding. The model corresponds to the fourteenth one. |
title | KH-I_Vigilin_rpt14 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26002083 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16315294 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14591919 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4091872 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4356732 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1189567 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2574771 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7037828 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28112537 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24666674 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11333162 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14588304 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5077392 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24704999 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1810108 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28965111 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8VDJ3 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9Z1A6 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ00341 |
Total number of triples: 22.